Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Lysine Specific Demethylase 1 (LSD1)
- Target
- LSD1
- Molecular classification
- Enzyme, Histone modification, Amine Oxidase
01
Overview
Lysine Specific Demethylase 1 (LSD1), also known as KDM1A, is a flavin-dependent amine oxidase that catalyzes the removal of methyl groups from mono-methylated and di-methylated lysines, specifically histone H3 at lysines K4 (H3K4me1/2) and K9 (H3K9me1/2). It plays a critical role in epigenetic regulation, influencing gene expression and various biological processes including development, hematopoiesis, and cell differentiation. LSD1 is also implicated in diseases such as cancer and cardiac remodeling, making it a potential therapeutic target.
- Other names
- KDM1ALysine-specific demethylase 1AAOF2Amine oxidase flavin-containing domain 2
02
Mechanism of action
Enzyme Inhibition
03
Biological functions
Epigenetic regulationTranscription regulationOocyte growthEmbryogenesisHematopoiesisCell differentiationChromatin remodeling
04
Disease associations
CancerCardiac Remodeling
Beyond the preview
Go deeper on Lysine Specific Demethylase 1 (LSD1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lysine Specific Demethylase 1 (LSD1).