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Target intelligence / Profile preview
Lysine-specific demethylase 4A (JMJD2A)
- Target
- JMJD2A
- Molecular classification
- Enzyme, Histone modification, Lysine demethylase
01
Overview
Lysine-specific demethylase 4A (JMJD2A) is a histone lysine demethylase that removes methyl groups from di- and trimethylated lysines on histone H3, primarily H3K9me2/3 and H3K36me2/3. It regulates chromatin structure and gene expression, acting as both a transcriptional repressor and a coactivator. JMJD2A is involved in various biological processes, including cell proliferation, differentiation, and tissue development, and it plays a role in diseases such as cancer and cardiac hypertrophy. It is considered a promising target for small-molecule inhibitors aimed at epigenetic therapy.
- Other names
- KDM4AJHDM3AKIA0677
02
Mechanism of action
Inhibition of histone demethylase activity, leading to altered gene expression profiles.
03
Biological functions
Chromatin remodelingRegulation of gene expressionCell proliferationCell migrationCell differentiationTissue development
04
Disease associations
CancerCardiac hypertrophy
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