Target intelligence / Profile preview

Lysine-specific demethylase 4B (KDM4B)

Target: KDM4B
Molecular classification: Enzyme, Histone modification, Transcription factor

Overview

Lysine-specific demethylase 4B (KDM4B) is a histone lysine demethylase that specifically removes methyl groups from trimethylated lysine 9 on histone H3 (H3K9me3), playing a key role in the regulation of gene expression through epigenetic modification of chromatin structure. It is involved in cell proliferation and differentiation, especially in neural tissues and dysregulation has been implicated in various cancers.

Other names: JMJD2BJHDM3BKIAA0876TDRD14BMRD65

Mechanism of action

Inhibition of H3K9me2/3 demethylation

Biological functions

Epigenetic regulationCNS developmentCell cycle controlCell proliferationCell differentiation

Disease associations

Cancer

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