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Target intelligence / Profile preview
Lysine-specific demethylase 4C (KDM4C)
- Target
- KDM4C
- Molecular classification
- Enzyme, Histone modification, Dioxygenase, Alpha-ketoglutarate-dependent hydroxylase
01
Overview
KDM4C is a histone demethylase that specifically removes methyl groups from H3K9me2/3 and H3K36me2/3, influencing gene expression and chromosome segregation. It plays a role in cancer development and progression, making it a potential therapeutic target.
- Other names
- JMJD2CJHDM3CGASC1Jumonji Domain Containing Protein 2CJHDM3c
02
Mechanism of action
Inhibition of histone demethylase activity by blocking the JmjC catalytic domain or disrupting protein-protein interactions.
03
Biological functions
Gene regulationChromosome segregationTranscriptional regulationChromatin remodeling
04
Disease associations
CancerEsophageal squamous cell carcinomaGlioblastomaHepatocellular carcinomaPolycythemia veraSquamous cell carcinoma
05
Safety considerations
Potential for off-target effects due to homology with other KDM4 family members.Disruption of normal histone methylation patterns may lead to unintended consequences on gene expression and cellular function.
06
Biomarkers
KDM4C expression levels in tumor tissueH3K9me3 levelsH3K36me3 levels
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