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Target intelligence / Profile preview
Lysine-specific demethylase 4E (KDM4E)
- Target
- KDM4E
- Molecular classification
- Enzyme, Histone demethylase, Jumonji C (JmjC) domain-containing histone demethylase
01
Overview
Lysine-specific demethylase 4E (KDM4E), also known as JMJD2E, is a histone lysine demethylase that removes methyl groups from lysine 9 on histone H3 (H3K9). It plays a role in epigenetic regulation by influencing chromatin structure and gene expression. KDM4E belongs to the KDM4/JMJD2 subfamily of histone demethylases and utilizes oxygen and 2-oxoglutarate as cofactors for its demethylation activity. It is being investigated as a potential therapeutic target, particularly in cancer.
- Other names
- JMJD2E
02
Mechanism of action
Inhibition of histone demethylase activity
03
Biological functions
Epigenetic regulationRegulation of gene expressionRegulation of chromatin structureHistone demethylation (H3K9)
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to similarity with other KDM4 family members
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