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Target intelligence / Profile preview
Lysine-specific demethylase 5A (KDM5A)
- Target
- KDM5A
- Molecular classification
- Enzyme, Histone modification, Trimethyllysine dioxygenase, Alpha-ketoglutarate-dependent hydroxylase
01
Overview
Lysine-specific demethylase 5A (KDM5A) is a nuclear enzyme that removes methyl groups from methylated lysine 4 of histone H3, playing crucial roles in gene regulation and cell differentiation. It has been implicated in cancer development and is a member of the KDM5/JARID1 family. KDM5A regulates gene transcription, influences mitochondrial function, and interacts with retinoblastoma protein (pRB). Its inhibition has shown promise in overriding differentiation blocks in cancer cells.
- Other names
- JARID1AJumonji/ARID domain-containing protein 1ARetinoblastoma Binding Protein 2 (RBP2)Lysine (K)-specific demethylase 5A
02
Mechanism of action
Inhibition of demethylase activity, disruption of protein-protein interactions
03
Biological functions
Transcriptional regulationCell proliferationCell differentiationRegulation of mitochondrial functionGene regulation
04
Disease associations
Cancer
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