Lysine-specific demethylase 5C (KDM5C)

Lysine-specific demethylase 5C (KDM5C) is an epigenetic enzyme of the JmjC domain-containing family that specifically demethylates tri- and di-methylated lysine 4 on histone H3 (H3K4me2/3), a marker of transcriptionally active chromatin[1][6]. KDM5C thereby plays a central role in transcriptional regulation by coordinating chromatin structure and gene expression dynamics during development, differentiation, mitochondrial metabolism, and immune function[1][3][5]. The enzyme is part of larger chromatin-modifying complexes and interacts with histone deacetylases, contributing to transcriptional repression and activation in a context-dependent manner[1][4]. Dysregulation or mutation of KDM5C is implicated in various cancers, neurological disorders, immune defects, and reproductive abnormalities such as recurrent miscarriage[2][5][7]. KDM5C is actively investigated as a therapeutic target, particularly in cancer and epigenetic therapy[1][2][3].

Other names

DXS1272EJARID1CSMCXXE169Histone demethylase JARID1CJumonji/ARID domain-containing protein 1CProtein SmcXProtein Xe169[histone H3]-trimethyl-L-lysine(4) demethylase 5CJmjC domain-containing protein SMCXMRX13MRXJMRXS16MRXSCJMRXSJSmcx homolog, X chromosomeSmcy homolog, X-linked

Inhibition of H3K4 demethylase activity, leading to increased H3K4 methylation and altered gene expression - Transcriptional reprogramming via modification of chromatin state