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Target intelligence / Profile preview
Lysine-specific demethylase 6B (JMJD3)
- Target
- JMJD3
- Molecular classification
- Enzyme, Histone modification, Transcription factor
01
Overview
Lysine-specific demethylase 6B (JMJD3/KDM6B) is a histone demethylase that specifically removes methyl groups from trimethylated lysine 27 on histone H3 (H3K27me3), altering chromatin structure and regulating gene expression. It plays roles in development, inflammation, and cancer, with context-dependent oncogenic or tumor-suppressive functions. Inhibitors like GSK-J1, GSK-J4, and JIB04 are used experimentally to study its epigenetic regulation.
- Other names
- KDM6BJumonji domain-containing protein 3
02
Mechanism of action
Histone demethylation (specifically H3K27me3)
03
Biological functions
Chromatin remodelingTranscriptional regulationCell differentiationCell proliferationInflammatory responseDevelopmental processesEpigenetic regulation
04
Disease associations
Neurodevelopmental disordersCancerInflammation
05
Safety considerations
Potential for off-target effects due to broad jumonji domain inhibitionContext-dependent oncogenic or tumor-suppressive roles complicate therapeutic targeting
06
Interacting drugs
GSK-J1
2 more in the full profile.
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