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Target intelligence / Profile preview
Lysine-specific demethylase RSBN1L (RSBN1L)
- Target
- RSBN1L
- Molecular classification
- Enzyme, Histone modification, Lysine-specific demethylase, RSBN1/Dpy-21/CEP530 family
01
Overview
Lysine-specific demethylase RSBN1L (RSBN1L) is an enzyme that catalyzes demethylation of methylated lysine residues within histone proteins, functioning in the epigenetic regulation of chromatin structure. Originally described as a testis-specific protein expressed in round spermatids, further studies indicate RSBN1L is expressed more broadly and is present in other germ cell stages. RSBN1L can demethylate both dimethyl and trimethyl lysine 20 on histone H4 (H4K20me2 and H4K20me3), converting them into monomethyl H4K20 (H4K20me1) and thereby influencing chromatin organization and gene expression during spermatogenesis. RSBN1L belongs to the RSBN1/Dpy-21/CEP530 family of demethylases[1][2]. At present, there are no documented drug interactions, disease associations, or direct clinical relevance for RSBN1L.
- Other names
- RSBN1LLysine-specific demethylase RSBN1LRound spermatid basic protein 1-like proteinFLJ42526FLJ45813MGC71764
02
Biological functions
Epigenetic regulationHistone lysine demethylationRegulation of spermatogenesis (especially in male germ cells)Modulation of nuclear architecture during cell differentiation
03
Disease associations
Other (no direct disease association documented)
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