LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3)

LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) is an evolutionarily conserved type II integral membrane protein that contains a lysin motif (LysM) domain, which is commonly associated with peptidoglycan binding[1][4]. In human and mouse cells, LYSMD3 is localized primarily to the Golgi apparatus and is essential for Golgi structural integrity[4][6]. Although its LysM domain suggests a potential role in innate immune functions or recognition of bacterial cell wall components, genetic knockout studies in mice have not established a clear in vivo physiological function for LYSMD3 and no deficiencies in immune response, inflammation, or intestinal microbiome were observed with its loss[1][2]. Orthologs exist across multiple species, highlighting evolutionary conservation, but no direct link to human disease or actionable therapeutic targeting is currently known[1][4].

Other names

LysM domain containing 3FLJ13542LYSMD3lysM and putative peptidoglycan-binding domain-containing protein 3