LysM domain containing protein 1 (LYSMD1)

LysM domain containing protein 1 (LYSMD1) is a human protein containing a LysM (lysin motif) domain, implicated in binding peptidoglycan and carbohydrate polymers, a function conserved across bacteria, archaea, and eukaryotes[6][3]. LYSMD1 acts as a positive regulator of lysosome-related organelle (LRO) biogenesis by interacting with the BLOC-3 guanine nucleotide exchange factor complex (specifically with its HPS1 subunit), enhancing activation of Rab32-family GTPases, which are essential for melanosome maturation and function in mammalian cells[2]. Knockdown of LYSMD1 and its paralog LYSMD2 causes LRO/melanosome defects, indicating partially redundant roles[2]. LYSMD1 has been associated with central nervous system expression and, in functional genomics screens, has emerged as a candidate oncogene in prostate cancer and as a marker for regulatory myeloid cell subsets influencing immune response[1][3]. To date, no drugs are known to target LYSMD1 and it is not considered a therapeutic target, receptor, enzyme, transporter, or transcription factor under standard molecular classifications. No direct clinical safety concerns or biomarker utilities beyond research applications have been reported.

Other names

LysM and putative peptidoglycan-binding domain-containing protein 1SB145MGC35223RP11-68I18.5LYSM1_HUMAN