Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Lysophosphatidic Acid (LPA)
- Target
- LPA
- Molecular classification
- Phospholipid derivative, Signaling molecule
01
Overview
Lysophosphatidic acid (LPA) is a simple, bioactive phospholipid that acts as a potent intercellular signaling molecule. It stimulates cell proliferation, survival, migration, and differentiation in multiple cell types. LPA plays roles in development, angiogenesis, wound healing, immune responses, and pathological conditions such as cancer progression and neuropathic pain. LPA exerts its effects mainly through binding to specific G protein-coupled receptors (GPCRs) known as LPARs. Aberrant regulation or overproduction/signaling through the autotaxin-LPA axis has been implicated in several diseases, making it a target for therapeutic intervention.
02
Mechanism of action
N/A
03
Biological functions
Extracellular signalingCell proliferationCell survival (anti-apoptotic)Cell migrationCell differentiationAngiogenesisImmune responses
04
Disease associations
CancerFibrosisNeuropathic painPruritus
05
Safety considerations
Aberrant regulation or overproduction/signaling implicated in several diseases.
Beyond the preview
Go deeper on Lysophosphatidic Acid (LPA).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lysophosphatidic Acid (LPA).