Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Lysophosphatidic acid pathway (LPA pathway)
- Target
- LPA pathway
- Molecular classification
- G protein-coupled receptor (for LPA receptors such as LPA₁–LPA₆), Enzyme (for autotaxin, which generates LPA), Lipid mediator pathway
01
Overview
The **lysophosphatidic acid pathway** involves signaling by lysophosphatidic acid, a bioactive phospholipid, through a family of G protein-coupled receptors (LPA₁–LPA₆) and key biosynthetic enzymes such as autotaxin. This pathway controls a range of cellular functions including proliferation, survival, migration, and angiogenesis, and contributes to pathological processes like cancer progression, fibrosis, and inflammation. Therapeutic interest centers on antagonists of LPA receptors and inhibitors of autotaxin for the treatment of oncology, fibrotic, and inflammatory diseases[1][2][3][4].
- Other names
- Lysophosphatidic acid signaling pathwayLPA signaling
02
Mechanism of action
Antagonism of LPA receptors to inhibit downstream GPCR signaling; Inhibition of autotaxin enzymatic activity to reduce LPA production
03
Biological functions
Signal transductionCell proliferationCell migration/invasionCell survival/anti-apoptosisAngiogenesisFibrosis/tissue repair
04
Disease associations
Cancer (including ovarian, hepatocellular, and others)Fibrosis (lung, hepatic, radiation-induced)InflammationNeurodegenerative diseaseCardiovascular disease
05
Safety considerations
Off-target effects due to wide physiological roles of LPA and its receptorsPotential for impaired tissue repair and wound healingRisk of affecting normal vascular and immune processes
06
Interacting drugs
SAR100842 (LPA₁ antagonist, for systemic sclerosis)
5 more in the full profile.
07
Biomarkers
Elevated plasma LPA level (prognostic for ovarian cancer)LPA receptor expression levels (e.g., LPA₁, LPA₂, LPA₃, LPA₆ in tissues)mRNA expression of LPA receptors in tumors as prognostic indicators
Beyond the preview
Go deeper on Lysophosphatidic acid pathway (LPA pathway).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lysophosphatidic acid pathway (LPA pathway).