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Target intelligence / Profile preview
Lysophosphatidic Acid Receptor (LPAR)
- Target
- LPAR
- Molecular classification
- G protein-coupled receptor
01
Overview
Lysophosphatidic acid receptors (LPARs) are a family of G protein-coupled receptors (GPCRs) that mediate the cellular effects of lysophosphatidic acid (LPA). LPARs play critical roles in regulating cell proliferation, survival, migration, cytoskeletal rearrangement, calcium mobilization, and other key physiological processes. Altered expression or activity of specific receptor subtypes has been linked to pathologies such as cancer progression/metastasis, nervous system disorders, cardiovascular disease, metabolic dysfunction, and inflammatory conditions.
02
Mechanism of action
G protein activation leading to downstream signaling pathways (Akt, Rho, MAPK, PLC)
03
Biological functions
Cell proliferationCell survivalCell migrationCalcium fluxCytoskeletal rearrangementMyelinationAdhesion
04
Disease associations
CancerNervous system disordersCardiovascular diseaseLiver diseaseMetabolic dysfunctionInflammatory diseases
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