Lysophosphatidic acid receptor 2 (LPAR2)

Lysophosphatidic acid receptor 2 (LPAR2) is a class A, G protein-coupled receptor encoded by the LPAR2 gene in humans, mediating cellular responses to the lipid mediator lysophosphatidic acid (LPA). LPAR2 couples predominantly with Gi and Gq proteins, triggering downstream signaling responsible for calcium mobilization, cytoskeletal changes, cell proliferation, anti-apoptosis, and DNA repair. It is highly expressed in immune cells and reproductive organs, with moderate expression in various adult tissues. LPAR2 has significant roles in cancer biology, inflammation, and tissue injury, including mucosal protection from NSAID-induced damage through promoting prostaglandin E production. Several selective agonists (e.g., DBIBB, GRI977143) have been developed, aiming for cytoprotection and tissue repair. It is considered a promising therapeutic target, but safety and specificity concerns persist due to its widespread physiological and pathological roles.

Other names

Edg4Pbx4pre-B-cell leukemia transcription factor 4endothelial differentiation gene 4lysophosphatidic acid G-protein-coupled receptor 4

Selective agonism of LPAR2 (promoting mucosal integrity, cytoprotection via prostaglandin E upregulation, facilitating cell survival/proliferation, and mitigation of apoptosis and tissue injury)