Lysophosphatidylglycerol acyltransferase 1 (LPGAT1)

Lysophosphatidylglycerol acyltransferase 1 is an enzyme of the lysophospholipid acyltransferase family responsible for catalyzing the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a critical component of membrane phospholipids and a precursor for cardiolipin synthesis[1][7]. In the endoplasmic reticulum, LPGAT1 contributes to the remodeling of fatty acyl chains in glycerophospholipids, displaying substrate specificity for saturated long-chain fatty acids (especially stearoyl CoA over palmitoyl CoA)[1]. The enzyme participates in pathways involving glycerophospholipid biosynthesis and broader lipid metabolic processes, influencing cellular lipid composition and potentially tissue lipid homeostasis and systemic metabolism[1][2][4][8]. Deficiency or mutation in LPGAT1 is associated with certain cardiac conduction disorders, notably Progressive familial heart block type II[1].

Other names

Lysophospholipid acyltransferase 1LGAT1