Lysoplasmalogenase TMEM86A (TMEM86A)

Lysoplasmalogenase TMEM86A is a transmembrane enzyme of the YhhN family that resides in the endoplasmic reticulum and catalyzes the hydrolysis of the vinyl ether bond in choline or ethanolamine lysoplasmalogens, producing fatty aldehyde and glycerophosphocholine (or glycerophosphoethanolamine)[3][4]. It is highly expressed in adipocytes, with additional activity observed in liver, duodenum, and other tissues[1][2]. TMEM86A regulates lysoplasmalogen metabolism, influences mitochondrial oxidative metabolism, and modulates PKA signaling in adipocytes by impacting PDE3B-mediated cAMP breakdown[1]. Loss of TMEM86A in adipocytes leads to increased lysoplasmalogen content, enhanced mitochondrial protein expression, and improved systemic metabolism in mice during high-fat feeding[1]. TMEM86A's enzymatic function distinguishes it from its paralog TMEM86B, as it displays substrate specificity for lysoplasmenylcholine over lysoplasmenylethanolamine[2]. No drugs are currently known to target TMEM86A, but its association with lipid metabolism disorders and the regulation of metabolic pathways make it a potential future therapeutic target for metabolic diseases[2][4].

Other names

Transmembrane protein 86AFLJ90119lysoplasmalogenase-like protein TMEM86ATMEM86Alysoplasmalogenase TMEM86A

Hydrolyzes the vinyl ether bond of choline or ethanolamine lysoplasmalogens to form fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine (i.e., catalyzes lysoplasmalogen breakdown)