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Lysosomal Acidification Pathway (None)

Target: None
Molecular classification: Enzyme, Transporter, Ion channel, Other

Overview

The lysosomal acidification pathway refers to the cellular processes that establish and maintain the acidic environment within lysosomes, which is essential for their degradative and signaling functions. Key components include the V-ATPase proton pump and counterion channels like CLC-7. Dysfunction is implicated in various diseases, making it a therapeutic target.

Mechanism of action

Inhibition of V-ATPase proton pumping; Modulation of counterion channel activity.

Biological functions

Degradation/recyclingAutophagyNutrient sensingImmunitypH regulation

Disease associations

Lysosomal storage diseasesNeurodegenerative diseasesCancerMetabolic disordersImmune dysfunctions

Safety considerations

Off-target effects due to broad expression of V-ATPaseDisruption of cellular homeostasisPotential impact on multiple cell types

Interacting drugs

V-ATPase inhibitors

2 more in the full profile.

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