Lysosomal-Associated Membrane Protein (LAMP)

Lysosomal-Associated Membrane Proteins (LAMPs) are integral membrane glycoproteins predominantly found in the lysosomal membrane. They are critical components of the lysosomal system, serving as the main intracellular mechanism for the turnover of endogenous and exogenous macromolecules. LAMPs help maintain lysosomal integrity, regulate pH, and are involved in autophagy and cell adhesion. LAMPs consist of LAMP-1 and LAMP-2, with LAMP-2 having isoforms LAMP-2A, LAMP-2B, and LAMP-2C. LAMP-2 deficiency is the primary defect in Danon disease.

Other names

LAMP-1LAMP-2Lysosome-associated membrane glycoprotein 1Lysosome-associated membrane glycoprotein 2