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Lysosomal Cholesterol
- Molecular classification
- Lipid, Sterol
01
Overview
Lysosomal cholesterol refers to the pool of cholesterol that is trafficked to, processed within, and exported from lysosomes—membrane-bound organelles responsible for degradation and recycling of various biomolecules. Lysosomes play a central role in cellular cholesterol homeostasis by processing low-density lipoprotein (LDL)-derived cholesteryl esters into free cholesterol, which is then distributed to other cellular compartments or stored as needed.
- Other names
- Cholesterol (lysosomal)Lysosomal free cholesterol
02
Biological functions
Cholesterol processingCholesterol exportLipid homeostasisIntracellular trafficking
03
Disease associations
AtherosclerosisNiemann-Pick Type C diseaseWolman diseaseLysosomal storage disordersCellular dysfunction related to autophagy
04
Safety considerations
Disruption of lysosomal cholesterol homeostasis can lead to accumulation and cellular dysfunction
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