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Target intelligence / Profile preview
Lysosome-associated membrane glycoprotein 2 (LAMP2)
- Target
- LAMP2
- Molecular classification
- Lysosome-associated membrane glycoprotein, Membrane protein
01
Overview
LAMP2 is a major lysosomal membrane protein that plays critical roles in autophagy, lysosomal biogenesis, pH regulation within the lysosome, and cellular homeostasis. It exists in three main isoforms (LAMP-2A, LAMP-2B, and LAMP-2C), each with specialized functions. Mutations or deficiency in LAMP2 are associated with Danon disease and hypertrophic cardiomyopathy. Autoantibodies against LAMP2 have been implicated in focal necrotizing glomerulonephritis. It is also implicated in tumor cell metastasis and exosome biology.
- Other names
- LAMP-2CD107bMac-3LGP110LAMPBCD107 antigen-like family member B
02
Biological functions
Autophagy regulationLysosomal maintenanceChaperone-mediated autophagyMacroautophagy/autolysosome formationLysosomal biogenesispH regulationInnate immune signalingExosome biology
03
Disease associations
Danon DiseaseHypertrophic CardiomyopathyFocal Necrotizing GlomerulonephritisTumor cell metastasis
04
Biomarkers
LAMP2 autoantibodies (Focal Necrotizing Glomerulonephritis)
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