Lysosome-associated Membrane Protein (LAMP)

Lysosome-associated membrane proteins (LAMPs) are a family of highly glycosylated, integral membrane proteins that constitute about 50% of the protein content in the lysosomal membrane. The most prominent members in mammals are LAMP1 and LAMP2, which play crucial roles in maintaining lysosomal integrity, regulating pH, and facilitating catabolic processes within the lysosome. LAMPs are involved in autophagy regulation and serve as carbohydrate ligands for selectins, mediating cell-cell adhesion. LAMP2 has three isoforms: LAMP2A, LAMP2B, and LAMP2C, each with specific functions. Deficiency or mutation in LAMP2 causes Danon disease. Overexpression/surface localization correlates with increased metastatic potential in several cancers.

Other names

LAMP1LAMP2LAMP2ALAMP2BLAMP2C