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Target intelligence / Profile preview
Lysosome-associated membrane protein 1 (LAMP1)
- Target
- LAMP1
- Molecular classification
- Lysosome-associated membrane glycoprotein, Type I transmembrane glycoprotein
01
Overview
Lysosome-associated membrane protein 1 (LAMP1) is a key glycoprotein predominantly found on the lysosomal membrane and plays essential roles in cellular homeostasis, immunity, and disease. It is involved in maintaining lysosomal integrity, regulating autophagy and lysosomal pH, cholesterol homeostasis, and immune responses. As CD107a, it serves as a marker for immune cell activation.
- Other names
- LAMP-1CD107alysosome-associated membrane glycoprotein 1
02
Biological functions
Maintains lysosomal integrity and structureRegulates autophagyLysosomal pH regulationCholesterol homeostasisImmune responseMarker of lymphocyte degranulation
03
Disease associations
Tumor progressionMetastasisCancerInfections
04
Biomarkers
CD107a (immune cell activation)
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