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Target intelligence / Profile preview
Lysosome-associated membrane protein 2 (LAMP2)
- Target
- LAMP2
- Molecular classification
- Lysosomal membrane protein, Type I transmembrane protein, Glycoprotein
01
Overview
Lysosome-associated membrane protein 2 (LAMP2), also known as CD107b, is a critical glycoprotein found in the lysosomal membrane. It plays essential roles in lysosome function, autophagy, and cellular homeostasis. Mutations or deficiencies in LAMP2 are associated with Danon Disease, hypertrophic cardiomyopathy, and may contribute to tumor metastasis. LAMP2 exists in three main isoforms: LAMP2A, LAMP2B, and LAMP2C, which differ in their functions and tissue distributions.
- Other names
- CD107bMac-3LGP110LAMPB
02
Biological functions
Lysosomal biogenesisRegulation of lysosomal pHChaperone-mediated autophagy receptorAutophagosome-lysosome fusionNucleic acid degradationCell adhesionLysosomal membrane integrity
03
Disease associations
Danon DiseaseHypertrophic cardiomyopathyFocal necrotizing glomerulonephritisTumor metastasis
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