Lysosome-Autophagosome Fusion via MTORC1 Pathway (N/A)

Lysosome-autophagosome fusion, regulated by the MTORC1 pathway, is a critical step in autophagy, enabling the degradation and recycling of cellular components. Active MTORC1, stimulated by nutrient availability, inhibits autophagy initiation and lysosomal function. Conversely, MTORC1 inactivation promotes autophagy. The fusion process involves Rab GTPases, SNARE proteins, tethering factors, and phosphoinositides. Dysregulation is implicated in various diseases, highlighting the importance of controlled autophagy.

Other names

Autophagy FluxAutolysosome FormationMTORC1-regulated AutophagyLysosomal Degradation Pathway

Varies depending on the specific intervention; MTOR inhibitors promote autophagy by de-repressing ULK1/2 and TFEB. Lysosomotropic agents disrupt lysosomal pH and function, impairing autophagic degradation.