Lysosome function and autophagy pathway

The lysosome function and autophagy pathway is a set of interconnected mechanisms by which cells degrade and recycle intracellular components and macromolecules via lysosome-dependent processes. The primary forms—macroautophagy, microautophagy, and chaperone-mediated autophagy—all culminate in the lysosomal degradation of cellular material. This pathway maintains cellular homeostasis, responds to metabolic stress, removes damaged organelles and proteins, and is implicated in numerous diseases including neurodegeneration, cancer, and lysosomal storage disorders.

Other names

Autophagy–lysosomal pathwayLysosomal degradation pathwayALP (autophagy–lysosomal pathway)

mTOR inhibition induces autophagy; Lysosomal pH modulation inhibits degradation; Fusion/fission inhibition affects vesicle flux.