Target intelligence / Profile preview

Lysosome pH Modulation

Molecular classification: Other

Overview

Lysosome acidification is essential for cellular waste processing and signaling functions. Hydroxychloroquine modulates this target by accumulating within these organelles and increasing their internal pH through its weak base action—thereby disrupting normal degradative processes critical to cell health and disease management.

Other names: Lysosomal acidificationIntralysosomal pH regulationLysosomal pH homeostasis

Mechanism of action

Weak base that accumulates in lysosomes, buffers protons, and raises the luminal pH, inhibiting enzyme activity and autophagic flux.

Biological functions

Regulation of autophagyRegulation of lysosomal enzyme activityMacromolecule degradationCellular waste processingSignal transduction

Disease associations

Neurodegenerative diseaseMetabolic disordersCancerImmune dysfunctionsInfection

Safety considerations

Drug-induced lysosomal storage disordersCardiotoxicity (with some agents)Retinopathy (with some agents)

Interacting drugs

Hydroxychloroquine

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