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Lysosome Stabilization
- Molecular classification
- Other
01
Overview
Lysosome stabilization refers to the cellular processes and molecular mechanisms that maintain the integrity of lysosomal membranes, preventing their rupture and uncontrolled release of hydrolytic enzymes into the cytoplasm. This is crucial for cell survival, as lysosomal membrane permeabilization can trigger cell death pathways and contribute to various diseases. Key mechanisms include glycocalyx protection by LAMP1/LAMP2, ESCRT-mediated resealing, ATG8 lipidation, transcriptional response via TFEB/TFE3, and the LYTL pathway involving LRRK2/RABs. Impaired stabilization can lead to neurodegeneration and cancer progression, while enhanced stability may treat degenerative diseases and increase tissue regeneration.
02
Mechanism of action
Enhancing membrane integrity or modulating key regulators like TFEB/LRRK2/RABs/LAMPs
03
Biological functions
Maintains integrity/functionality of degradative compartmentPrevents cell deathAutophagy regulation
04
Disease associations
NeurodegenerationCancer progressionAging-related decline in proteostasis
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