Target intelligence / Profile preview

Lysyl Hydroxylase (LH)

Target: LH
Molecular classification: Enzyme, Dioxygenase, Hydroxylase, Glycosyltransferase (LH3 isoform)

Overview

Lysyl hydroxylase is an enzyme that catalyzes the hydroxylation of lysine residues in collagen, a post-translational modification critical for collagen cross-linking and stability. There are three isoforms (LH1, LH2, LH3), each with distinct substrate preferences. Inhibiting lysyl hydroxylase can disrupt collagen maturation and stability, impacting the structure of connective tissues.

Other names: Procollagen-Lysine 5-Dioxygenase

Mechanism of action

Inhibition of lysyl hydroxylation, leading to disruption of collagen cross-linking.

Biological functions

Collagen maturationCollagen cross-linkingExtracellular matrix (ECM) stabilityLysine hydroxylationCollagen glycosylation (LH3 isoform)

Disease associations

Ehlers-Danlos syndromeConnective tissue disordersBone fragility disorders

Safety considerations

Potential disruption of normal collagen structure and function leading to connective tissue abnormalities.Non-specific inhibition may affect multiple collagen types with varying consequences.

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