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Lysyl Oxidase (LOX)
- Target
- LOX
- Molecular classification
- Enzyme, Amine Oxidase
01
Overview
Lysyl oxidase (LOX) is a copper-dependent amine oxidase enzyme that plays a central role in the biogenesis and maintenance of connective tissue matrices. Its primary function is to catalyze the oxidative deamination of specific lysine residues in collagen and elastin precursors, converting them into reactive aldehydes (allysine). These aldehydes then participate in covalent cross-linking reactions, which are essential for stabilizing the extracellular matrix (ECM) by forming mature collagen fibrils and elastic fibers. LOX expression is regulated by various factors, and dysregulation has been linked with tumor progression due to effects on cell migration/invasion via ECM remodeling. Inhibition of LOX is explored as a strategy to treat fibrotic diseases and cancer.
02
Mechanism of action
Inhibition of lysyl oxidase activity, preventing ECM cross-linking
03
Biological functions
ECM Cross-LinkingTissue DevelopmentCell Behavior ModulationOxidative deamination of peptidyl lysinesExtracellular matrix organization
04
Disease associations
FibrosisCancerLathyrismMenkes diseaseConnective Tissue Disorders
05
Safety considerations
Potential off-target effects on related amine oxidasesDisruption of normal ECM homeostasis if completely inhibited
06
Interacting drugs
PXS-5505
1 more in the full profile.
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