Target intelligence / Profile preview

Lysyl Oxidase Homolog 2 (LOXL2)

Target: LOXL2
Molecular classification: Enzyme, Amine Oxidase, Lysyl Oxidase Family

Overview

Lysyl oxidase homolog 2 (LOXL2) is a secreted, copper-dependent amine oxidase enzyme that plays a crucial role in extracellular matrix (ECM) remodeling by catalyzing the cross-linking of collagen and elastin. It is implicated in various diseases, including cancer and fibrosis, due to its involvement in tumor invasiveness, metastasis, and ECM stability. Targeting LOXL2 has emerged as a therapeutic strategy for these conditions.

Mechanism of action

Inhibition of LOXL2 enzymatic activity

Biological functions

Cross-linking collagen/elastinRegulation of angiogenesisModulation of cell signalingECM remodelingCell proliferationCell survival

Disease associations

CancerFibrosis

Interacting drugs

Simtuzumab

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