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Target intelligence / Profile preview
Lysyl Oxidase-Like 2 Protein (LOXL2)
- Target
- LOXL2
- Molecular classification
- Enzyme, Amine oxidase, Lysyl oxidase
01
Overview
LOXL2 is a member of the lysyl oxidase family, a group of secreted, copper-dependent amine oxidases that catalyze the oxidative deamination of lysine residues on target proteins, a critical step in cross-linking extracellular matrix proteins like collagen and elastin. It plays roles in connective tissue remodeling, tumor progression, and fibrosis, making it a therapeutic target. LOXL2 is involved beyond ECM remodeling and affects developmental regulation, senescence, tumor suppression or promotion, cell growth control, and chemotaxis. Expression is up-regulated in several cancers and fibrotic diseases such as liver fibrosis.
02
Mechanism of action
Inhibition of LOXL2 enzymatic activity
03
Biological functions
Extracellular matrix remodelingConnective tissue biogenesisCell growth controlChemotaxisDevelopmental regulationSenescenceHistone modification
04
Disease associations
CancerFibrotic diseasesLiver fibrosis
05
Interacting drugs
Simtuzumab
06
Biomarkers
LOXL2 expression levels in tumor tissue
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