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Target intelligence / Profile preview
Lysyl Oxidase-Like Protein 1 (LOXL1)
- Target
- LOXL1
- Molecular classification
- Enzyme, Amine Oxidase, Lysyl Oxidase Family
01
Overview
LOXL1 is an extracellular copper-dependent amine oxidase crucial for the stabilization and maintenance of collagen and elastin fibers. It plays a significant role in elastic fiber homeostasis and matrix remodeling, with implications in diseases like pseudoexfoliation syndrome/glaucoma, fibrosis, cutis laxa, and cancer.
- Other names
- Lysyl oxidase homolog 1LOLLysyl oxidase-like protein 1
02
Mechanism of action
LOXL1 catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in covalent cross-links that stabilize these fibers.
03
Biological functions
Elastin biogenesisCollagen cross-linkingElastic fiber homeostasisMatrix remodeling
04
Disease associations
Pseudoexfoliation syndrome/glaucomaFibrotic diseasesCutis LaxaCancer progression
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