Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Lysyl Oxidase-like Protein 2 (LOXL2)
- Target
- LOXL2
- Molecular classification
- Enzyme, Amine Oxidase, Lysyl Oxidase Family
01
Overview
Lysyl oxidase-like protein 2 (LOXL2) is an enzyme that belongs to the lysyl oxidase family. It plays a critical role in the biogenesis of connective tissue by catalyzing crosslinking of collagen and elastin fibers. LOXL2 is a copper-dependent amine oxidase that mediates post-translational oxidative deamination of lysine residues on target proteins, leading to the formation of allysine and subsequent cross-linking. It is essential for extracellular matrix remodeling and is implicated in various diseases including cancer and fibrotic conditions. Several inhibitors targeting LOXL2 are under investigation as potential therapeutics.
- Other names
- LOX-Like Protein 2LOX homolog 2LOX-Like 2
02
Mechanism of action
Inhibition of LOXL2 enzymatic activity, preventing collagen and elastin crosslinking and downstream effects on cell motility and ECM remodeling.
03
Biological functions
Extracellular matrix remodelingCollagen crosslinkingElastin crosslinkingAngiogenesis regulationDevelopmental regulationSenescenceTumor suppressionCell growth controlChemotaxis
04
Disease associations
CancerFibrotic diseasesLiver fibrosisCardiovascular disease (Vascular stiffening)
05
Safety considerations
Off-target effects of LOXL2 inhibitors on related enzymes or substrates.
06
Interacting drugs
Simtuzumab
2 more in the full profile.
Beyond the preview
Go deeper on Lysyl Oxidase-like Protein 2 (LOXL2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Lysyl Oxidase-like Protein 2 (LOXL2).