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Target intelligence / Profile preview
Lysyl oxidase-like protein 3 (LOXL3)
- Target
- LOXL3
- Molecular classification
- Enzyme, Amine oxidase, Lysyl oxidase family
01
Overview
Lysyl oxidase-like protein 3 (LOXL3) is a copper-dependent amine oxidase enzyme that catalyzes the oxidative deamination of peptidyl lysine residues in collagen and elastin, initiating crosslinking essential for extracellular matrix stability. It plays a role in development, fibrosis, and cancer progression, including EMT and metastasis. It is a potential therapeutic target in diseases such as fibrosis and cancer. Silencing leads to reduced signaling through NFκB/AKT/ERK/JNK pathways involved in inflammation/fibrosis/adipogenesis.
02
Mechanism of action
Inhibition of LOXL3 reduces collagen/elastin crosslinking and EMT
03
Biological functions
Extracellular matrix remodelingCollagen crosslinkingElastin crosslinkingConnective tissue biogenesisEpithelial-mesenchymal transition (EMT)Cell proliferationCell invasionMetastasis
04
Disease associations
Stickler syndromeMyopiaCleft palateFibrosisCancer
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