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Lysyl-tRNA synthetase (LysRS)

Target: LysRS
Molecular classification: Enzyme, Aminoacyl-tRNA synthetase

Overview

Lysyl-tRNA synthetase (LysRS) is an essential enzyme that catalyzes the attachment of the amino acid lysine to its corresponding tRNA (tRNALys), a critical step in protein synthesis. This process, known as aminoacylation, ensures that lysine is correctly incorporated into proteins during translation. It is a therapeutic target for antibiotic development against pathogens like Mycobacterium tuberculosis.

Other names: Lysine-tRNA ligaseLysine-tRNA synthetase

Mechanism of action

Inhibition of lysyl-tRNA synthetase

Biological functions

AminoacylationProtein biosynthesisTranslation

Disease associations

Infection

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