Müllerian duct tissue (null)

Müllerian duct tissue consists of paired embryonic structures (the Müllerian/paramesonephric ducts) that develop early in fetal life and differentiate into the female reproductive tract, specifically the fallopian tubes, uterus, cervix, and upper vagina. In males, these ducts regress under the influence of anti-Müllerian hormone (AMH), but in females, they persist and form organs necessary for female fertility and pregnancy. The tissue is made up of both epithelial and mesenchymal cell layers and is regulated by complex developmental signaling pathways, including Wnt/β-catenin, LHX1, and various transcription factors. Anomalies in the formation, fusion, or resorption of these ducts can result in congenital defects such as uterine aplasia, bicornuate uterus, or septate uterus, often associated with infertility or reproductive complications. This is not a discrete protein, receptor, or single molecular entity, but a developmental tissue composed of many cell types and pathways.

Other names

Paramesonephric duct tissueMüllerian ductsparamesonephric tissueMD tissue

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