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Target intelligence / Profile preview
Cell division cycle 25C phosphatase (CDC25C)
- Target
- CDC25C
- Molecular classification
- Cdc25 phosphatase family, Dual-specificity protein tyrosine phosphatases, Enzyme
01
Overview
Cdc25C phosphatase is a key regulatory enzyme involved in cell cycle control, specifically the transition from G2 phase to mitosis. It functions as a dual-specificity phosphatase, primarily targeting cyclin-dependent kinases (CDKs) to promote cell division. Its activity is tightly regulated via phosphorylation and interactions with other proteins involved in checkpoint control. Dysregulation contributes directly to genomic instability and cancer development, making it an important therapeutic target.
- Other names
- M-phase inducer phosphatase 3
02
Mechanism of action
Inhibition of phosphatase activity; preventing CDK1 dephosphorylation
03
Biological functions
Cell cycle regulationDNA damage responseMitotic entryG2/M transitionSuppression of growth arrest
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to homology with other phosphatasesDisruption of normal cell cycle control leading to toxicity
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