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Target intelligence / Profile preview
M-phase phosphoprotein 1 (None)
- Target
- None
- Molecular classification
- Kinesin, Molecular Motor
01
Overview
M-phase phosphoprotein 1 (MPP1), also known as kinesin-like protein KIF20B, is a plus-end-directed kinesin-related molecular motor essential for cytokinesis. It localizes to the midzone and midbody during cell division, ensuring proper separation of daughter cells. Autoantibodies against MPP1 have been detected in patients with neuropsychiatric systemic lupus erythematosus (NPSLE), suggesting a potential role in the pathogenesis of SLE-related cranial neuropathies. It acts as a slow-moving motor along microtubules.
- Other names
- MPP1Kinesin-like protein KIF20B
02
Mechanism of action
Inhibition of microtubule-dependent motor activity
03
Biological functions
Cell cycleMitosisCytokinesisMicrotubule bindingATPase activity
04
Disease associations
Neuropsychiatric systemic lupus erythematosus (NPSLE)
05
Safety considerations
Potential for disruption of cell division in healthy tissues if targeted therapeuticallyAutoimmunity
06
Biomarkers
Anti-MPP1 antibodies
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