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M1 Family of Aminopeptidases
- Molecular classification
- Enzyme, Metalloaminopeptidases, Metalloprotein
01
Overview
The M1 family of aminopeptidases is a large group of zinc-dependent metalloenzymes that catalyze the removal of amino acids from the N-terminus of polypeptides. These enzymes are characterized by two conserved catalytic sequence motifs: a consensus zinc-binding motif (HEXXH-(X18)-E) and the 'GXMEN' exopeptidase motif. Members are found across all domains of life and play essential roles in protein digestion, cell signaling, immune response, peptide hormone regulation, and other physiological processes. They are potential drug targets for cancer and infectious diseases like malaria.
02
Mechanism of action
Inhibition of aminopeptidase activity
03
Biological functions
Protein digestionCell signalingImmune responsePeptide hormone regulationProtein/peptide turnoverImmune modulationHormone processing
04
Disease associations
CancerInfection
05
Safety considerations
Off-target effects due to structural conservation across family members
06
Biomarkers
ANPEP/CD13 in cancer
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