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Target intelligence / Profile preview
M2 Macrophage Polarization (M2 Polarization)
- Target
- M2 Polarization
- Molecular classification
- Cellular State, Immune Cell Polarization, Phenotype
01
Overview
M2 macrophage polarization is the process by which macrophages adopt an "alternatively activated" phenotype, typically in response to specific environmental cues such as cytokines IL-4, IL-13, and IL-10. This state is characterized by anti-inflammatory functions, tissue repair activities, immune regulation, and promotion of tumor progression in certain contexts. It is a dynamic process, and macrophages can repolarize between M1 and M2 states.
- Other names
- Alternative Macrophage ActivationM2 ActivationType 2 Macrophage Polarization
02
Biological functions
Anti-inflammationTissue RepairTissue RemodelingImmune RegulationAngiogenesis (in tumor microenvironment)Immunosuppression (in tumor microenvironment)
03
Disease associations
FibrosisWound HealingCancer (Tumor Progression)Systemic Sclerosis
04
Safety considerations
Excessive M2 polarization can lead to fibrosis and tumor progression.Therapeutic targeting is complicated by macrophage plasticity.
05
Biomarkers
Arginase 1CD163CD206CCL17CCL22CCL24IL-10TGF-β
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