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Target intelligence / Profile preview
M4 Muscarinic Acetylcholine Receptor (None specified)
- Target
- None specified
- Molecular classification
- G protein-coupled receptor, GPCR, Receptor
01
Overview
The M4 muscarinic acetylcholine receptor (M4 mAChR), encoded by the CHRM4 gene, is a Gi/o-coupled GPCR that acts as an inhibitory autoreceptor for acetylcholine, particularly in the striatum. It regulates dopaminergic neurotransmission and plays a role in extrapyramidal motor control. M4 mAChR is implicated in various neurological disorders and represents a therapeutic target for Alzheimer's disease, schizophrenia, Parkinson's disease, and other conditions such as myelodysplastic syndrome and anemia.
- Other names
- CHRM4Muscarinic acetylcholine receptor M4
02
Mechanism of action
Gi/o-mediated inhibition of adenylate cyclase; modulation of potassium channels and phosphoinositide breakdown.
03
Biological functions
Signal transductionAutoreceptor functionRegulation of neurotransmitter releaseRegulation of dopaminergic neurotransmission
04
Disease associations
Movement disordersParkinson's diseaseAlzheimer's diseaseSchizophreniaMyelodysplastic syndromeAnemiaPsychiatric disordersCognitive disorders
05
Safety considerations
Potential for side effects due to non-selective targeting of other muscarinic receptor subtypes.
06
Interacting drugs
Acetylcholine
6 more in the full profile.
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