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Macrophage Checkpoint SIRPα Pathway
- Molecular classification
- Signaling pathway, Immune checkpoint
01
Overview
The macrophage checkpoint SIRPα pathway is a critical immune regulatory axis involving the interaction between Signal Regulatory Protein Alpha (SIRPα) and its ligand CD47. This pathway functions as an inhibitory "don't eat me" signal that prevents macrophages and other myeloid cells from phagocytosing healthy self-cells, but is also exploited by cancer cells to evade immune clearance.
02
Mechanism of action
Blockade of CD47-SIRPα interaction, promoting phagocytosis of cancer cells
03
Biological functions
Immune regulationInhibition of phagocytosisSelf/non-self discriminationInnate immunity regulation
04
Disease associations
CancerInflammationImmune evasion
05
Safety considerations
On-target toxicity due to broad CD47 expressionAnemia due to erythrocyte phagocytosisThrombocytopenia
06
Interacting drugs
Anti-CD47 antibodies
1 more in the full profile.
07
Biomarkers
CD47 expression level on tumor cellsSIRPα expression level on macrophages
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