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Target intelligence / Profile preview
Colony Stimulating Factor 1 (CSF1)
- Target
- CSF1
- Molecular classification
- Cytokine, Growth factor
01
Overview
Colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine that plays a central role in the regulation of survival, proliferation, differentiation, and function of mononuclear phagocytes—primarily macrophages and their progenitors. It exerts its biological effects by binding to the high-affinity cell-surface tyrosine kinase receptor CSF-1R. Targeting the CSF1/CSF1R axis has become an area for therapeutic intervention, particularly in oncology settings, due to its role in modulating tumor-associated macrophages.
- Other names
- Macrophage colony-stimulating factorM-CSF
02
Mechanism of action
Inhibition of CSF1 signaling, either by directly targeting the CSF1 ligand or the CSF1R receptor.
03
Biological functions
HematopoiesisRegulation of mononuclear phagocyte survivalRegulation of mononuclear phagocyte proliferationRegulation of mononuclear phagocyte differentiationRegulation of mononuclear phagocyte functionChemotaxisCell migrationTissue repairHomeostasis
04
Disease associations
Cancer progressionInnate immunityInflammationSystemic lupus erythematosus (SLE)ArthritisAtherosclerosisObesity-related inflammation
05
Safety considerations
Modulation of tumor-associated immune cellsPotential impact on normal macrophage functionSafety profiles are still under investigation in trials
06
Interacting drugs
Emactuzumab
2 more in the full profile.
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