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Target intelligence / Profile preview
Macrophage colony-stimulating factor 1 receptor (CSF1R)
- Target
- CSF1R
- Molecular classification
- Receptor, Type III protein tyrosine kinase receptor, Transmembrane protein
01
Overview
Macrophage colony-stimulating factor 1 receptor (CSF1R), also known as M-CSFR, CD115, or c-FMS, is a cell-surface transmembrane protein encoded by the CSF1R gene. It is a member of the type III protein tyrosine kinase receptor family and plays a central role in regulating the survival, proliferation, and differentiation of myeloid lineage cells, especially macrophages and microglia. Upon ligand binding (CSF-1 or IL34), the receptor dimerizes and activates downstream signaling pathways including PI3K/Akt, JNK, ERK/MAPK pathways. Mutations in CSF1R are linked to several diseases including ALSP, cancer, and skeletal disorders. Therapeutic targeting of CSF1R is under clinical investigation for various diseases.
- Other names
- M-CSFRCD115c-FMS
02
Mechanism of action
Inhibition of CSF1R kinase activity; depletion or repolarization of tumor-promoting macrophages
03
Biological functions
Cell survivalCell proliferationCell differentiationSignal transductionActin cytoskeleton reorganizationBone remodelingCNS homeostasis
04
Disease associations
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)CancerSkeletal dysplasia
05
Safety considerations
Variable efficacy depending on disease contextTolerability needs careful monitoring
06
Interacting drugs
CSF1R inhibitors
1 more in the full profile.
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