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Macrophage M1 Polarization Factors (M1 Polarization Factors)
- Target
- M1 Polarization Factors
- Molecular classification
- Cytokine, Transcription Factor, Metabolic Enzyme, Receptor, Chemokine, Surface Marker
01
Overview
Factors involved in promoting M1 macrophage polarization, including cytokines (IFN-γ, TNF-α), transcription factors (STAT1, NF-κB, IRF5), metabolic pathways (glycolysis), and surface markers/chemokines (CD80, CD86, CCL2, CCL3, CCL4, CCL5). These factors play a critical role in the pro-inflammatory response of macrophages.
- Other names
- M1 Macrophage PolarizationM1 ActivationClassical Macrophage Activation
02
Biological functions
Immune responseInflammationPathogen clearanceAntigen presentationCell signalingGene regulationMetabolic regulation
03
Disease associations
InfectionInflammationAutoimmune diseaseCancerSepsisTissue damage
04
Safety considerations
Excessive inflammationTissue damageCytokine stormAutoimmunity
05
Biomarkers
CD80 expressionCD86 expressionHLA-DR expressionCCL2 levelsCCL3 levelsCCL4 levelsCCL5 levelsIFN-γ levelsTNF-α levels
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