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Target intelligence / Profile preview
Macrophage Mannose Receptor (CD206)
- Target
- CD206
- Molecular classification
- C-type lectin family, Type I transmembrane protein, Receptor
01
Overview
The macrophage mannose receptor (MR), also known as CD206 or MRC1, is a type I transmembrane glycoprotein and a member of the C-type lectin family. It is predominantly expressed on most tissue macrophages, dendritic cells, and certain lymphatic or endothelial cells. It plays a central role in innate immunity through its role in pathogen recognition and endocytic clearance mechanisms, and also serves as a biomarker/target for imaging inflammatory diseases/tumors due to its selective expression profile on alternatively activated macrophages.
- Other names
- MRMRC1
02
Mechanism of action
Selective activation of CD206 on M2-polarized macrophages to enhance phagocytosis/autophagy/apoptosis.
03
Biological functions
EndocytosisPhagocytosisAntigen presentationPathogen recognitionImmune homeostasisClearance of mannoglycoproteins
04
Disease associations
InflammationTumor progressionInfection
05
Safety considerations
Potential for off-target effects due to broad expression on macrophages.Modulation of immune responses may have unintended consequences.
06
Interacting drugs
RP-182
07
Biomarkers
sMR (soluble Macrophage Mannose Receptor)
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