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Target intelligence / Profile preview
Macrophage Metalloelastase (MMP-12)
- Target
- MMP-12
- Molecular classification
- Metalloproteinase, Matrix Metalloproteinase, Enzyme
01
Overview
Macrophage metalloelastase (MMP-12) is a zinc-dependent endopeptidase belonging to the matrix metalloproteinase family. Primarily expressed by mature tissue macrophages, it exhibits significant elastolytic activity, degrading elastin and other ECM components. MMP-12 plays a crucial role in tissue remodeling during inflammation and injury, facilitating macrophage migration. It is implicated in various diseases, including emphysema, atherosclerosis, and rheumatoid arthritis. Expression is modulated by factors like hyaluronic acid fragments, interferon-gamma, and dexamethasone. Loss-of-function studies highlight its importance in macrophage-mediated ECM proteolysis and tissue invasion.
- Other names
- Matrix metallopeptidase 12MME
02
Mechanism of action
Inhibition of MMP-12 enzymatic activity, preventing degradation of ECM components.
03
Biological functions
Extracellular matrix degradationTissue remodelingMacrophage migrationElastolysis
04
Disease associations
EmphysemaAtherosclerosisRheumatoid arthritisSkin diseasesAbdominal aortic aneurysmsObesityInsulin resistanceChronic inflammatory respiratory diseases
05
Safety considerations
Potential for off-target effects due to broad substrate specificity of MMPs.Risk of disrupting normal tissue remodeling processes.
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