Macrophage Polarization Toward M2 Phenotype (M2 Macrophage Polarization)

Macrophage polarization toward the M2 phenotype is a process by which macrophages differentiate into an alternatively activated state. M2 macrophages are involved in tissue repair, resolution of inflammation, and immune regulation. They are induced by cytokines such as IL-4, IL-10, and IL-13, and are characterized by the expression of markers such as CD206 and arginase 1, as well as the secretion of anti-inflammatory cytokines. While M2 macrophages are important for normal tissue homeostasis, excessive M2 polarization can contribute to disease progression in contexts such as cancer and chronic infection.

Other names

Alternative Macrophage ActivationM2 Macrophage ActivationM2 PolarizationType 2 Macrophage Polarization

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