Macrophage scavenger receptor 1 (MSR1) and CD36 molecule (CD36) (MSR1/CD36)

Macrophage scavenger receptor 1 (MSR1, also known as SRA) and CD36 are integral membrane glycoproteins that serve as the primary receptors for the uptake of modified lipoproteins by macrophages [1][2]. In the context of cardiovascular disease, these receptors recognize and internalize oxidized low-density lipoprotein (oxLDL), leading to the accumulation of intracellular cholesterol and the subsequent transformation of macrophages into foam cells [3]. This process is a fundamental driver of atherosclerotic plaque formation and progression. Additionally, both receptors function as pattern recognition receptors (PRRs) involved in the innate immune response, binding various ligands including bacterial components and apoptotic cells [4]. Therapeutic targeting of these receptors focuses on inhibiting lipid uptake or modulating their inflammatory signaling pathways to treat atherosclerosis and metabolic disorders [5]. Experimental inhibitors and monoclonal antibodies are being investigated to selectively block these receptors without compromising overall immune function [6].

Other names

Scavenger receptor class AMSR1CD204Scavenger receptor class B member 3SCARB3Fatty acid translocaseFATGlycoprotein IVgpIVSR-AISR-AII

Inhibition of oxidized LDL (oxLDL) uptake and modulation of fatty acid transport to prevent macrophage foam cell formation and reduce chronic inflammatory signaling.